Scientist, Cryo-Electron Microscopy at GSK in Rockville, MD

Scientist, Cryo-Electron Microscopy

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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK’s long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

The US Structural Biology Center of Excellence (CoE) at GSK, a new joint Vaccines and Pharma Center, will be established in Cambridge, MA in 2025. The mission of the CoE is to apply the full range of structural biology, protein biochemistry, and computational tools to design vaccines as well as to antibodies, biologics, and small molecules.

We’re looking for a passionate and highly motivated structural biologist to join the CoE. As a critical member of our team, you will be at the center of our state-of-the-art, structure determination and protein design operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be responsible for assisting in antigen design, structure determination and interpretation to support vaccine or medicine lead identification and progression. The position will require active collaboration with diverse teams to work together and address key challenges.

This role will initially be located at the GSK’s Rockville site in Maryland from 2024 to 2025, and will permanently move to Cambridge, Massachusetts afterwards.

Key Responsibilities:

Assist in developing design strategies, implement screening funnels and other mechanistic studies to support vaccine or medicine lead identification, validation and progression.
Collaborate with the protein production, molecular design, and biophysics teams to propose constructs based on computational or structure-based design principles for all aspects of project progression.
Assist in designing and implement procedures to conduct advanced research and experiments in cryo-EM or other methods to deliver structural solutions to project teams.
Deliver reagents and structural data to impact projects through protein expression & purification, vitrification, data collection, and three-dimensional structure determination using cryo-EM or other related methodologies.
Use and maintain the equipment in a state-of-the-art EM laboratory.
Interpret the results of experiments and make scientific conclusions.
Document your work and ensure appropriate quality control experiments are carried out to support intellectual property and reagent reuse by other groups.

Basic Qualifications:

PhD in a structural biology related field with a focus on cryo-EM.
MS in a structural biology related field with a focus on cryo-EM and 2+ years' experience.
Minimum 1 year's hands-on experience in protein expression, biochemistry, sample vitrification, negative staining, data collection, and single particle analysis.
Minimum 1 year's hands-on experience in the operation of electron microscopy equipment and cryo-electron microscopes.
Minimum 1 year's hands-on experience with computational modelling and analysis of protein structures.

Preferred Qualifications:

Post-Doctoral or industrial research experience in protein biochemistry, transmission electron microscopy, molecular modelling, molecular biology, computational biology, or other related discipline.
Experience with other macromolecular structural determination methods such as electron tomography, or X-ray crystallography.
Demonstrated success solving high-resolution structures including small proteins, protein complexes, or membrane proteins.
Knowledge of biophysical techniques such as mass photometry, mass spectroscopy, differential scanning fluorimetry, high performance liquid chromatography, size exclusion chromatography, differential scanning calorimetry, isothermal titration calorimetry, bio-layer interferometry and surface plasmon resonance is a plus.
Experience in Bash shell scripting, Python, R, SQL, C++, JavaScript or other relevant programming languages.
Experience with computational modelling and analysis of protein structures, and structure-based design of small molecule drugs, antibodies and vaccine is a plus.
Excellent oral and written communication skills with a fluency in English.
Able to efficiently manage uncertainty, changes in priority and timeline restrictions.

#Vx-Cam

#Li-GSK

The annual base salary for new hires in this position ranges from $85,850 to $116,150 taking into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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