Job Description

At our company, we are committed to improving the health and well-being of people around the world. As a leading global pharmaceutical company, we strive to make a difference through innovative research and development of life-saving medications and vaccines. Our company's Research Laboratories in South San Francisco is seeking a Principal Scientist of In vivo Pharmacology with strong experience in cardiovascular and metabolic diseases to join our Quantitative Biosciences (Pharmacology) department as an in vivo team lead. Working collaboratively with multidisciplinary scientists and through your team, you will apply your knowledge of translational models for cardiometabolic diseases, in vivo technology platforms, and data science to advance diverse therapeutic programs. If you are lab-focused, scientifically curious, and looking to develop your career at a leading science driven pharmaceutical company, we'd love for you to be part of our diverse and passionate team.

Key responsibilities:

• Develop and support in vivo pharmacology strategies for obesity, immuno-metabolic, and cardiovascular diseases to enable a robust drug discovery pipeline

• Lead translational model development and implementation to support target engagement, pharmacodynamics, or efficacy studies

• Serve as a core member in matrixed project teams and governance committees to drive in vivo pharmacology strategy and provide scientific/technical leadership

• Ensure high-quality data generation, analysis, and reporting to project teams, governance committees, and regulatory agencies, and manage key timelines and milestones

• Lead and develop a group of PhD and non-PhD researchers, drive scientific innovation, and champion new enabling technologies to enhance functional capability and productivity

• Monitor emerging biology, biomarker, as well as basic & clinical research in cardiometabolic disorders to influence portfolio development strategy

• Collaborate extensively across our company's network and with external partners to drive pipeline progression toward key milestones

Qualifications:

Education:

• Ph.D. in biology, pharmacology, metabolism, immunology or related discipline and relevant industry experience listed below

Required Experience and Skills:

• A minimum of 10 years of drug discovery experience at a biotech or pharmaceutical setting in obesity, dysmetabolism, diabetes and cardiovascular complications, with a proven track record substantiated by peer-reviewed publications and/or patents

• A solid understanding of cardiometabolic disease pathogenesis and extensive experience indeveloping relevant in vivomodels including both small and large animals

• Experience leading discovery teams, overseeing in vivo strategy, setting project priorities, and managing resources

• A robust understanding of preclinical drug discovery and clinical development

• An excellent track record of providing mentorship to direct reports and influencing peers

• The ability to communicate effectively with and relate to a broad range of stakeholders, including senior leaders, peers, direct reports, partners, and external collaborators

Preferred Experience and Skills:

• Strong knowledge of biomarker discovery, translational research, and data science

• Prior experience working with multiple therapeutic modalities (small molecule, peptide, biologic, etc.)

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected US salary range:

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R311021