Job Description

At our company, we are committed to improving the health and well-being of people around the world. As a leading global pharmaceutical company, we strive to make a difference through innovative research, discovery, and development of life-saving medications and vaccines. With over a century of experience and a steadfast dedication to scientific excellence, we have become a trusted name in the industry. Join our team and be a part of our mission to create a healthier future for all.

We are seeking a highly motivated and innovative Associate Principal Scientist to join our Biochemistry & Mass Spectrometry team within the Mass Spectrometry & Biophysics (MSB) Department in Quantitative Biosciences. Our team utilizes multidisciplinary techniques to characterize ligand-protein interactions and modulation of (target) protein function to support early-stage drug discovery across a broad spectrum of therapeutic modalities.

Applicants will ideally have a strong background in protein mass spectrometry and prior experience in hydrogen-deuterium exchange mass spectrometry (HDX-MS) or related techniques to characterize ligand-protein and protein-protein interactions. The successful candidate will be part of cross-functional teams and will collaborate across diverse therapeutic areas including Oncology, Immunology, Neuroscience, Cardiometabolic and Infectious Diseases.

Key Responsibilities:

• Utilize HDX-MS and other protein footprinting techniques to characterize protein higher order structure and dynamics, as well as ligand-protein and protein-protein interactions.

• Perform intact protein and peptide mapping experiments to identify cleavage patterns, covalent modification, PTMs and differential expression patterns.

• Collaborate with colleagues in our Biochemistry, Biophysics, BioNMR and Protein & Structural Chemistry teams to deliver an integrated view of protein conformation and interactions.

• Serve as a representative on cross-functional program teams with accountability for delivering progress updates, presenting data & contributing to strategic direction.

• Stay abreast of advancements in the field of protein and biophysical mass spectrometry and drive innovation through platform development, internal/external collaboration & long-range capability planning.

• Contribute to a high-performance culture of inclusion, collaboration, engagement and self-accountability.

• Promote the external reputation of our department through publications and participating in external symposia.

Minimum Education Required:

• Post-graduate degree in Analytical Chemistry, Structural Biology, Biochemistry or another related field with 5+ years of relevant industry experience: Ph.D. (5+ years), M.Sc. (7+ years) or B.Sc. (13+ years).

Essential Qualifications:

• Broad expertise in protein mass spectrometry/proteomics, including hands-on experience performing HDX-MS studies, is required.

• Ability to independently trouble-shoot hardware and software complications and liaise directly with field service engineers to resolve issues as needed.

• Experience performing technology evaluations & making recommendations on investments designed to maintain a leadership position in the field.

• Demonstrated passion for fostering a diverse and inclusive culture and contributing to the growth and success of colleagues.

• Strong external reputation as evidenced through high-impact publications, presentations, and scientific community engagement.

• Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.

Desirable Experience and Skills:

• Prior experience with additional structural mass spectrometry techniques for characterizing ligand-protein interactions such as FPOP, photoaffinity labeling and native mass spectrometry would be a significant advantage.

• Knowledge of structural techniques such as bioNMR, x-ray crystallography and cryo-electron microscopy is beneficial.

• Experience with classical protein biochemistry techniques including gel electrophoresis, western blotting, enzymatic digestion, protein/peptide fractionation, SEC, DLS, etc. is advantageous.

• Prior experience with membrane protein characterization is desirable.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected US salary range:

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

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Flexible Work Arrangements:

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Requisition ID:R318397